Sometime before episode 12, we learn Harime Nui lost her left eye from Matoi Isshin slashing her with a half-scissor.
Around episode 20, Harime Nui is pierced through the chest by Ryuuko, also by a half-scissor, but that time, she did not experience pain and healed from this more serious wound instantly.
It is also revealed that Harime Nui was fused with Life Fibers from birth having been developed inside a Life Fiber cocoon.
Given these facts, why did
Harime Nui experience pain when slashed by Isshin?
Her eye not heal from the wound?