Warning: Some spoilers below.
If you look at the succeeding pages of Chapter 112, Eren does indeed say that he hates Mikasa and revealed that he has done so ever since they were kids.
Whether he means it or not, however, is a different matter altogether. He could or could not be lying. The reason for him doing so or if he did lie, we cannot know yet as of now due to lack of information.
What we do know, however, is that in Chapter 115,
it was revealed that Eren and Zeke had a talk, with Eren agreeing to Zeke's plan of genocide to wipe out the Eldian race. The reason being that if they were never born in the first place, there would be no suffering and Eren views it as their 'salvation'. Him pushing away everyone he knows, including his two close friends, Armin and Mikasa, was probably to ease the pain he would feel and sever any attachment or feelings he felt towards the two, knowing that he would be responsible for their deaths soon, if their plan succeeds.
Would it be possible for Eren and Mikasa to fight? This is speculation but I think this can be substantiated by facts mentioned in Chapter 112. In that same chapter,
it was revealed that Ackermans awaken their powers when they recognize someone as a 'host'. Eren was recognized by Mikasa as her host and someone she had to protect so I doubt that she would be able to hurt him. Even when Eren said those harsh words and Armin was about to punch Eren, Mikasa still stopped Armin, following her clan's 'instincts' when awakened.