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In the first Pokemon Movie we see that Mewtwo is actually artificially created by Team Rocket and not a naturally occurring Pokemon.

According to this answer there are 2 Mewtwo's and the second female one is still possibly artificially created.

In the trailers for Detective Pikachu (I have not seen the movie yet) we see Mewtwo appear in it. I am wondering if this Mewtwo is one we already know from the anime movies? Or are there now possibly 3 Mewtwo's

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Spoilers ahead.

Haven't watched the movies or anime, but I play the games, and according to this article, this Mewtwo

is the same Mewtwo that appeared in the original Pokemon anime and movie two decades ago. The movie referred to here is Pokémon: The First Movie. This was the Mewtwo from the Kanto region which escaped Team Rocket.

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    I saw the movie, so I can confirm this is correct – Wondercricket 2 days ago

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