Which came out first Fullmetal Alchemist the manga, Fullmetal Alchemist the anime or Fullmetal Alchemist Brotherhood?
The manga is the original production. The anime equivalent was loosely based on that manga, until the production caught up with the manga. At that point, the anime took its own initiative and came up with a story. Brotherhood is a re-make of the entire completed manga, and is pretty much the same as the manga is.