I feel no Uchiha showed any efforts in stopping the Uchiha massacre.
Why did no Uchiha use Izanami or Izanagi on Itachi and Obito?
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Sign up to join this communityIzanami and Izanagi were forbidden techniques. Also, only few among Uchiha could use them.
Moreover, Izanagi in particular had quite a large downside of blindness.
From what is shown in the Anime, people probably knew of Izanagi, but were not skilled enough to use it. Izanami was probably known to only a few people, as evidenced by Itachi and Sasuke's conversation during their fight with Kabuto.
Another issue is that both of these techniques require a bit of preparation. The massacre by Itachi and Obito were very sudden and wildly unexpected. Thus, even if anybody had the knowledge of the techniques, I don't think they had the time to think of using them!